What organelles do pancreatic cells have a lot of? Pancreatic acinar cells are highly specialized for digestive enzyme synthesis, storage, and secretion 17, therefore they have abundant endoplasmic reticulum (ER) to meet the protein synthesis rate, the highest among all adult human tissues 18-21.
Why do pancreatic cells have lots of endoplasmic reticulum? Pancreatic beta cells have well-developed endoplasmic reticulum (ER) to accommodate for the massive production and secretion of insulin. ER homeostasis is vital for normal beta cell function. Perturbation of ER homeostasis contributes to beta cell dysfunction in both type 1 and type 2 diabetes.